H. Li, X.D. Yang, G.Q. Lin, P. Tian, One-pot preparation of 9,10-dihydrophenanthrenes initiated by rhodium (III)-catalyzed C activation and relay Diels-Alder reaction, Org. Lett.Appendix A. Supplementary information Supplementary data to this article is often found on the web at doi.org/10.1016/j.ejmech.2021.114030.
cancersArticleThe Landscape of Transmembrane Protein Family Members in Head and Neck Cancers: Their Biological Part and Diagnostic UtilityOliwia Koteluk 1, , , Antonina Bielicka 1, , , Zaneta Lemanska 1 , Kacper J wiak 1 , Weronika Klawiter 1 , z 1,2 , Urszula Kazimierczak 1 and Tomasz Kolenda 1,2,3 Andrzej MackiewiczDepartment of Cancer Immunology, Chair of Health-related Biotechnology, Poznan University of Health-related Sciences, 8 Rokietnicka Street, 60-806 Poznan, Poland; zazet13@gmail (Z.L.); kacperjozwiak97@gmail (K.J.); klawweronika@gmail (W.K.); [email protected] (A.M.); ukazimierczak@gmail (U.K.); kolenda.tomek@gmail (T.K.) Department of Diagnostics and Cancer Immunology, Higher Poland Cancer Centre, 15 Garbary Street, 61-866 Poznan, Poland Laboratory of Cancer Genetics, Greater Poland Cancer Centre, 15 Garbary Street, 61-866 Poznan, Poland Correspondence: oliwiakoteluk@gmail (O.K.); antonina.bielicka@gmail (A.B.) These authors contributed equally.Citation: Koteluk, O.; Bielicka, A.; Lemanska, Z.; J wiak, K.; z Klawiter, W.; Mackiewicz, A.; Kazimierczak, U.; Kolenda, T. The Landscape of Transmembrane Protein Family members Members in Head and Neck Cancers: Their Biological Function and Diagnostic CYP1 manufacturer Utility. Cancers 2021, 13, 4737. doi.org/10.3390/ cancers13194737 Academic MAP4K1/HPK1 manufacturer Editors: Vinita Takiar and Sana D. Karam Received: 19 August 2021 Accepted: 17 September 2021 Published: 22 SeptemberSimple Summary: Transmembrane proteins (TMEM) are a sizable group of integral membrane proteins whose molecular and biological functions are certainly not fully understood. It is recognized that a few of them are involved in tumor formation and metastasis. Right here, we performed a panel of TCGA data analyses to investigate the part of distinct TMEM genes in head and neck squamous cell carcinoma (HNSCC) and define their prospective as biomarkers. According to modifications inside the expression levels in HNSCC tumors, we chosen 4 TMEM genes: ANO1, TMEM156, TMEM173, and TMEM213 and related them with patient survival. We also demonstrated that the expression of those TMEMs extremely correlates with the enrichment of genes involved in several biological processes, especially metastasis formation and immune response. As a result, we propose ANO1, TMEM156, TMEM173, and TMEM213 as new biomarkers and potential targets for customized therapy of HNSCC. Abstract: Background: Transmembrane proteins (TMEM) constitute a large household of proteins spanning the entirety from the lipid bilayer. Nevertheless, there is still a lack of expertise about their function or mechanism of action. In this study, we analyzed the expression of chosen TMEM genes in individuals with head and neck squamous cell carcinoma (HNSCC) to discover their role in tumor formation and metastasis. Supplies and Strategies: Utilizing TCGA data, we analyzed the expression levels of diverse TMEMs in both regular and tumor samples and compared those two groups according to clinicalpathological parameters. We selected 4 TMEMs whose expression was highly correlated with patient survival status and subjected them to further evaluation. The pathway analysis applying REACTOME and the gene set enrichment evaluation (GSEA) had been performed to evaluate the association of thos
