Product Name: AV-951 (Tivozanib) | VEGFR1/2/3, cKit, PDGFR inhibitor
Product Description: AV-951 is an potent and selective orally bioavailable isoxazole inhibitor of VEGFR1, 2, and 3, kinases at 0.21, 0.16, and 0.24 nM, respectively. Additionally it has nanomolar activity for cKIT and PDGFR at 1.63 and 1.72 nM, respectively. [1] In vitro, AV-Medchemexpress.com
Chemical Formula: C22H19ClN4O5
Molecular Weight: 454.86
‘&“CAS NO: 1639042-08-2 AZD9496
Purity: 98%
Appearance: Off White
Chemical Name: 1-(2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)ureaHistone Methyltransferase inhibitors
Solubility: Up to 100 mM in DMSO
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage Condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.PubMed ID:http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_toc_pr?p_JournalID=2&p_IssueID=329
