Rations of directionally selective cells, are nevertheless dominated by a magnocellular input and give robust CP 472295 clinical trials responses to visual motion stimulation [13,32 ?4]. As our sole concern was whether it is possible to relate the strength of cortical activity in early visual areas with subjective preference, we did not think it useful, for the present study, to try and subdivide the active areas further with retinotopic mapping or to search for subdivisions or groupings within them for which responses correlate with preference, although both approaches will be of interest for future studies.5.1. Strength of activation and motion-sensitive areas of the cortexEven though directionally selective cells are most prominently concentrated in area V5 and its satellites (the V5 complex), several other visual areas have been described as containing them. These include areas V1, V2, V3, V3A and V3B, all of which have been responsive to stimulation with visual motion in human fMRI (��)-BGB-3111 structure experiments, to varying degrees [12]. Of these, it is area V5 that has been the most extensively studied, with results that are now generally agreed upon. Chief among these are that its cells are overwhelmingly responsive to motion, that the great majority are directionally selective and that most are indifferent to both the colour and the form of the stimulus [5,8,35]. Indeed, many respond optimally to a spot or spots moving in the appropriate direction. It is almost certain that the activity of neurons in V5 is at the basis of the perception of motion in both monkey and human [22,36,37], with the behavioural, psychometric functions and the physiological, neurometric ones from V5 cells in monkeys being almost identical [38]. These characteristics make it relatively easy to prepare visual stimuli that activate V5 strongly. In this study, we opted for patterns of dots in motion in the fronto-parallel plane, known to activate human V5 [30,32], with patterns of incoherently moving dots being more potent activators than a pattern of coherently moving ones [32,39], presumably because more directionally selective cells are activated with incoherently moving patterns. The areas that were prominently active in the contrast motion more than static were not identical to those in which there was relationship between BOLD signal and preference. In particular, areas V1 and V2 showed no activity related to preference. Activity related to preference was seen only in the V3 complex, V5, parietal cortex and field A1 of mOFC (neither of the latter two areas having shown activity in the contrast motion . static). While the directionally selective cells of V1 respond to component motion of stimuli and those of V5 to their direction of motion [40], the directionally selective cells of areas V2 and V3 have been rather less extensively studied. Area V3 is less directionally selective than V5 in both monkey and human [9,13], but has been found to be responsive to visual motion stimulation in several human studies. Areas V3A and V3B (which are not easily distinguishable from one another even with retinotopic mapping [16,41]) are located dorsally in the brain but represent both upper and lower quadrants [42], also contain directionally selective cells [9] and have been reported, in the human, to be more responsive tomotion than V3, though not as responsive as V5 [10,13]. Cells responsive to more complex types of motion, including optic flow patterns, have also been described in both monkey [43,44] and hum.Rations of directionally selective cells, are nevertheless dominated by a magnocellular input and give robust responses to visual motion stimulation [13,32 ?4]. As our sole concern was whether it is possible to relate the strength of cortical activity in early visual areas with subjective preference, we did not think it useful, for the present study, to try and subdivide the active areas further with retinotopic mapping or to search for subdivisions or groupings within them for which responses correlate with preference, although both approaches will be of interest for future studies.5.1. Strength of activation and motion-sensitive areas of the cortexEven though directionally selective cells are most prominently concentrated in area V5 and its satellites (the V5 complex), several other visual areas have been described as containing them. These include areas V1, V2, V3, V3A and V3B, all of which have been responsive to stimulation with visual motion in human fMRI experiments, to varying degrees [12]. Of these, it is area V5 that has been the most extensively studied, with results that are now generally agreed upon. Chief among these are that its cells are overwhelmingly responsive to motion, that the great majority are directionally selective and that most are indifferent to both the colour and the form of the stimulus [5,8,35]. Indeed, many respond optimally to a spot or spots moving in the appropriate direction. It is almost certain that the activity of neurons in V5 is at the basis of the perception of motion in both monkey and human [22,36,37], with the behavioural, psychometric functions and the physiological, neurometric ones from V5 cells in monkeys being almost identical [38]. These characteristics make it relatively easy to prepare visual stimuli that activate V5 strongly. In this study, we opted for patterns of dots in motion in the fronto-parallel plane, known to activate human V5 [30,32], with patterns of incoherently moving dots being more potent activators than a pattern of coherently moving ones [32,39], presumably because more directionally selective cells are activated with incoherently moving patterns. The areas that were prominently active in the contrast motion more than static were not identical to those in which there was relationship between BOLD signal and preference. In particular, areas V1 and V2 showed no activity related to preference. Activity related to preference was seen only in the V3 complex, V5, parietal cortex and field A1 of mOFC (neither of the latter two areas having shown activity in the contrast motion . static). While the directionally selective cells of V1 respond to component motion of stimuli and those of V5 to their direction of motion [40], the directionally selective cells of areas V2 and V3 have been rather less extensively studied. Area V3 is less directionally selective than V5 in both monkey and human [9,13], but has been found to be responsive to visual motion stimulation in several human studies. Areas V3A and V3B (which are not easily distinguishable from one another even with retinotopic mapping [16,41]) are located dorsally in the brain but represent both upper and lower quadrants [42], also contain directionally selective cells [9] and have been reported, in the human, to be more responsive tomotion than V3, though not as responsive as V5 [10,13]. Cells responsive to more complex types of motion, including optic flow patterns, have also been described in both monkey [43,44] and hum.
