Vykhodtseva N, Jolesz FA Noninvasive MR imaging-guided focal opening from the blood-brain barrier in rabbits. Radiology 220: 640646. six. Sheikov N, McDannold N, Vykhodtseva N, Jolesz F, Hynynen K Cellular mechanisms from the blood-brain barrier opening inhibitor induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30: 979989. 7. Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, et al. Focal disruption of your blood-brain barrier because of 260-kHz ultrasound eight. bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg 105: 445454. Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, et al. Targeted delivery of doxorubicin towards the rat brain at therapeutic levels applying MRI-guided focused ultrasound. Int J Cancer 121: 901907. Liu HL, Hua MY, Chen PY, Chu Computer, Pan CH, et al. Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 255: 415425. Park EJ, Zhang YZ, Vykhodtseva N, McDannold N Ultrasoundmediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab within a breast cancer brain metastasis model. J Control Release 163: 277284. Yang FY, Wong TT, Teng MC, Liu RS, Lu M, et al. Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor impact in glioblastoma multiforme. J Control Release 160: 652658. Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, et al. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer’s disease mouse models. PLoS One 3: e2175. Jordao JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, et al. Antibodies targeted for the brain with image-guided focused ultrasound reduces 9. ten. 11. 12. 13. 8 Delivery of hEPO by MBs/FUS for Neuroprotection 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer’s disease. PLoS One particular five: e10549. Weng JC, Wu SK, Lin WL, Tseng WY Detecting blood-brain barrier disruption within minimal hemorrhage following transcranial focused ultrasound: a correlation study with contrast-enhanced MRI. Magn Reson Med 65: 802811. Nagao M, Suga H, Okano M, Masuda S, Narita H, et al. Nucleotide sequence of rat erythropoietin. Biochim Biophys Acta 1171: 99102. Wen D, Boissel JP, Tracy TE, Gruninger RH, Mulcahy LS, et al. Erythropoietin structure-function relationships: high degree of sequence homology amongst mammals. Blood 82: 15071516. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic anxiety. Proc Natl Acad Sci U S A 98: 40444049. Villa P, Bigini P, Mennini T, Agnello D, Laragione T, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198: 971975. Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, et al. Decreased functional deficits, neuroinflammation, and secondary tissue damage just after remedy of stroke by nonerythropoietic erythropoietin Autophagy derivatives. J Cereb Blood Flow Metab 17493865 27: 552563. Ishii T, Asai T, Urakami T, Oku N Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion. Brain Res 1321: 164168. Yanamoto H, Nagata I, Niitsu Y, Xue JH, Zhang Z, et al. Evaluation of MCAO stroke models in normotensive rats: standardized neocortical infarction by the 3VO strategy. Exp Neurol.Vykhodtseva N, Jolesz FA Noninvasive MR imaging-guided focal opening from the blood-brain barrier in rabbits. Radiology 220: 640646. 6. Sheikov N, McDannold N, Vykhodtseva N, Jolesz F, Hynynen K Cellular mechanisms on the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30: 979989. 7. Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, et al. Focal disruption from the blood-brain barrier resulting from 260-kHz ultrasound eight. bursts: a approach for molecular imaging and targeted drug delivery. J Neurosurg 105: 445454. Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, et al. Targeted delivery of doxorubicin to the rat brain at therapeutic levels employing MRI-guided focused ultrasound. Int J Cancer 121: 901907. Liu HL, Hua MY, Chen PY, Chu Pc, Pan CH, et al. Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 255: 415425. Park EJ, Zhang YZ, Vykhodtseva N, McDannold N Ultrasoundmediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab inside a breast cancer brain metastasis model. J Handle Release 163: 277284. Yang FY, Wong TT, Teng MC, Liu RS, Lu M, et al. Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. J Control Release 160: 652658. Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, et al. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer’s disease mouse models. PLoS One three: e2175. Jordao JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, et al. Antibodies targeted for the brain with image-guided focused ultrasound reduces 9. 10. 11. 12. 13. eight Delivery of hEPO by MBs/FUS for Neuroprotection 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. amyloid-beta plaque load inside the TgCRND8 mouse model of Alzheimer’s illness. PLoS One 5: e10549. Weng JC, Wu SK, Lin WL, Tseng WY Detecting blood-brain barrier disruption inside minimal hemorrhage following transcranial focused ultrasound: a correlation study with contrast-enhanced MRI. Magn Reson Med 65: 802811. Nagao M, Suga H, Okano M, Masuda S, Narita H, et al. Nucleotide sequence of rat erythropoietin. Biochim Biophys Acta 1171: 99102. Wen D, Boissel JP, Tracy TE, Gruninger RH, Mulcahy LS, et al. Erythropoietin structure-function relationships: high degree of sequence homology among mammals. Blood 82: 15071516. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, et al. Erythropoietin prevents neuronal apoptosis following cerebral ischemia and metabolic anxiety. Proc Natl Acad Sci U S A 98: 40444049. Villa P, Bigini P, Mennini T, Agnello D, Laragione T, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198: 971975. Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, et al. Decreased functional deficits, neuroinflammation, and secondary tissue harm soon after remedy of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab 17493865 27: 552563. Ishii T, Asai T, Urakami T, Oku N Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion. Brain Res 1321: 164168. Yanamoto H, Nagata I, Niitsu Y, Xue JH, Zhang Z, et al. Evaluation of MCAO stroke models in normotensive rats: standardized neocortical infarction by the 3VO strategy. Exp Neurol.
