Product Name: LDE225
Chemical Name: N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)-[1,1′-biphenyl]-3-carboxamide
SMILES Code: O=C(C1=C(C)C(C2=CC=C(OC(F)(F)F)C=C2)=CC=C1)NC3=CC=C(N4C[C@@H](C)O[C@@H](C)C4)N=C3
CAS NO: 379270-38-9 Product: JW 642
Synonym: LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib
Chemical Formula: C26H26F3N3O3
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).DNA_RNA Synthesis inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: LDE225 (NVP-LDE225; Erismodegib) is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/9014759
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Product Name: LDE225
Chemical Name: N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
SMILES Code: CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
CAS NO: 59721-29-8 Product: Actinomycin D
Synonym: LDE 225; NVP-LDE 225; Erismodegib; LDE-225; Sonidegib
Chemical Formula: C26H26F3N3O3
Appearance: Solid powderWeb Site click
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Potassium Channel inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/%2020667732