Product Name :
CCR2 antagonist 4 hydrochloride
Description:
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
CAS:
1313730-14-1
Molecular Weight:
476.32
Formula:
C21H22Cl2F3N3O2
Chemical Name:
N-[(3S)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]-2-[3-(trifluoromethyl)phenyl]formamidoacetamide hydrochloride
Smiles :
Cl.O=C(CNC(=O)C1C=C(C=CC=1)C(F)(F)F)N[C@@H]1CN(CC2C=CC(Cl)=CC=2)CC1
InChiKey:
PGUQBBISBKGQDC-FERBBOLQSA-N
InChi :
InChI=1S/C21H21ClF3N3O2.ClH/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25;/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29);1H/t18-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.|Product information|CAS Number: 1313730-14-1|Molecular Weight: 476.32|Formula: C21H22Cl2F3N3O2|Chemical Name: N-[(3S)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]-2-[3-(trifluoromethyl)phenyl]formamidoacetamide hydrochloride|Smiles: Cl.O=C(CNC(=O)C1C=C(C=CC=1)C(F)(F)F)N[C@@H]1CN(CC2C=CC(Cl)=CC=2)CC1|InChiKey: PGUQBBISBKGQDC-FERBBOLQSA-N|InChi: InChI=1S/C21H21ClF3N3O2.ClH/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25;/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29);1H/t18-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (524.86 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Chrysene-d12 Autophagy |Shelf Life: ≥12 months if stored properly.Amlodipine Epigenetics |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32796418 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ile263 and Thr292 in CCR2 contribute significantly to binding of CCR2 antagonist 4 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride.|In Vivo:|In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.|Products are for research use only. Not for human use.|
