Product Name :
Cathepsin L Inhibitor
CAS NO. :
167498-29-5
Formula :
C26H26O5N2
Molecular Weight::
446.50
Target:
Cathepsin
Serial Number:
Cbz-Phe-Tyr-CHO
Short serial number :
Z-FY-CHO
Purity:
95%
Description :
Z-Phe-Tyrosinal is a potent and selective cathepsin L inhibitor. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone.
References:
[1].Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. [2]. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. [3]. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
CD86 Rabbit pAb Protocol
Garadacimab Formula
Alexa Fluor® 594-conjugated AffiniPure Goat Anti-Mouse IgG H&L : Alexa Fluor® 594-conjugated AffiniPure Goat Anti-Mouse IgG H&L is an orange Fluor® 594-conjugated and Goat origined monoclonal antibody, targeting to Mouse IgG antibody. Alexa Fluor® 594-conjugated AffiniPure Goat Anti-Mouse IgG H&L can binds to the light and heavy chains of Mouse IgG antibodies, thus can be used for ICC/IF, IHC-F, FC, ELISA assays in the background of Mouse.
