Product Name :
[DArg1, DTrp5, 7, 9, Leu11] Substance P
CAS NO. :
122481-75-8
Formula :
C81H110N20O12
Molecular Weight::
1555.87
Target:
Glyoxalase (GLO)
Serial Number:
DArg-Pro-Lys-Pro-DTrp-Gln-DTrp-Phe-DTrp-Leu-Leu-NH2
Short serial number :
rPKPwQwFwLL-NH2
Purity:
95%
Description :
This substance P analog is a very potent broad-spectrum neuropeptide inhibitor for small cell lung cancer (SCLC) cell growth in vitro (IC₅₀ = 5 µM). Moreover it potently inhibited signal transduction pathways in vitro and significantly delayed the growth of an SCLC xenograft in vivo. It could therefore be of therapeutic value in SCLC.
References:
[1]. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. [2]. [D-Arg1,D-Trp5,7,9,Leu11]Substance P coordinately and reversibly inhibits bombesin- and vasopressin-induced signal transduction pathways in Swiss 3T3 cells.
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