Product Name :
Caspase 3 (Apopain) Inhibitor 1
CAS NO. :
184179-08-6
Formula :
C20H30O11N4
Molecular Weight::
502.47
Target:
Serial Number:
Ac-Asp-Glu-Val-Asp-CHO
Short serial number :
Ac-DEVD-CHO
Purity:
95%
Description :
Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC₅₀ = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC₅₀ = 10 to 100 nM).Ac-DEVD-CHO acetate is a specific inhibitor of Caspase-3.Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
References:
[1]. The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines. [2]. Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes. [3]. Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Erenumab CGRP Receptor
C5b-9 Antibody Purity & Documentation
EpCAM Antibody (YA772): EpCAM Antibody (YA772) is a non-conjugated and Mouse origined monoclonal antibody about 35 kDa, targeting to EpCAM. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse.
