Product Name :
Pep-1-Cysteamine
CAS NO. :
863608-35-9
Formula :
C140H202O33N36S1
Molecular Weight::
2949.39
Target:
others
Serial Number:
Ac-Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val-Cysteamine
Short serial number :
Ac-KETWWETWWTEWSQPKKKRKV-Cysteamine
Purity:
95%
Description :
Pep-1 is a synthetic cell-penetrating peptide (CPP) that has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive manner. It is a CPP with primary amphipathicity that comprises a tryptophan-rich so-called “hydrophobic” domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. The C-terminal cysteamine group appears to play a crucial role in the delivery efficiency of cargoes into cells.
References:
[1]. Sónia Troeira Henriques, et al. Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1. Mol Membr Biol. 2007 Jul-Aug;24(4):282-93.
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