Hippuryl-His-Leu-OH | DNA_ Alkylatingdna-alkylating.com

Product Name :
Hippuryl-His-Leu-OH

CAS NO. :
31373-65-6

Formula :
C21H27O5N5

Molecular Weight::
429.47

Target:
Amino Acid Derivatives Angiotensin-converting Enzyme (ACE)

Serial Number:
Benzoyl-Gly-His-Leu-OH

Short serial number :
Bz-GHL

Purity:
95%

Description :
Substrate for a spectrophotometric assay of angiotensin I-converting enzyme. ACE cleavage of Hip-His-Leu yields hippuric acid and His-Leu (G-2310), which can be quantified by generating a fluorescent adduct with o-phthalaldehyde. Schwager et al. developed a high-throughput fluorometric assay for ACE employing Hip-His-Leu.

References:
[1]. Nishimura K, et al. Purification of angiotensin I-converting enzyme from human lung. Biochim Biophys Acta. 1977 Aug 11;483(2):398-408. [2]. Santos RA, et al. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension. 1985 Mar-Apr;7(2):244-52. [3]. Horiuchi M, et al. Method for determination of angiotensin-converting enzyme activity in blood and tissue by high-performance liquid chromatography. J Chromatogr. 1982 Dec 10;233:123-30.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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