Product Name :
Mca-YVADAP-K(Dnp)
CAS NO. :
189696-01-3
Formula :
C53H64O19N10
Molecular Weight::
1145.13
Target:
Caspase Angiotensin-converting Enzyme (ACE)
Serial Number:
MCA-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH
Short serial number :
Mca-YVADAP-K(Dnp)
Purity:
95%
Description :
Specific highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp) at the P1 Asp residue results in a continuous fluorescent assay monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Both caspase-1 and caspase-3 are involved in apoptosis. A specific substrate for renal ACE 2.
References:
[1]. Susan Acton, et al. Preparation of amino acid derivatives for modulating angiotensin converting enzyme-2 (ACE-2). US20040082496A1
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