Product Name :
NGR peptide
CAS NO. :
651328-78-8
Formula :
C20H34N10O8S2
Molecular Weight::
606.68
Target:
Aminopeptidase
Serial Number:
Cys-Asn-Gly-Arg-Cys-Gly-OH(Disulfide Bridge:Cys1-Cys5)
Short serial number :
CNGRCG-OH(Disulfide Bridge:C1-C5)
Purity:
95%
Description :
NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.It is a peptide with NGR (Asn-Gly-Arg) motif, which has a disulfide bridge linking cys1 and cys5, and is known to have antimicrobial properties in addition to the presence of KLA sequences. The peptide binds to CD13 on tumor cells and shows strong cytotoxicity and activity against tumor cells. This peptide shows dose-dependent antiproliferation against tumor cells and induces cell cylce arrest at G2/M phases and apoptosis of the tumor cells. Peptides containing the NGR motif are useful in the delivery of cytotoxic drugs, pro-apoptotic peptides, and tumor necrosis factor (TNF) into tumor vasculature.
References:
[1]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46. [2]. Ma W, et al. Biodistribution and SPECT imaging study of (99m)Tc labeling NGR peptide in nude mice bearing human HepG2 hepatoma. Biomed Res Int. 2014;2014:618096.
Related websites: https://www.medchemexpress.com/antibodies.html
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