Product Name :
Polymyxin B nonapeptide TFA
CAS NO. :
2220175-42-6
Formula :
C43H74N14O11.5C2HF3O2
Molecular Weight::
1533.25
Target:
Bacterial Antibiotic
Serial Number:
Thr-Dab-Dab-Dab-Dab-DPhe-Leu-Dab-Dab-Thr(Lactam:Dab3-Thr9)
Short serial number :
T-{Dab-Dab-Dab-Dab}-{DPhe-Leu-Dab-Dab}-T(Lactam:Dab3-Thr9)
Purity:
95%
Description :
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue.Polymyxin B nonapeptide interacts with the outer membrane of gram-negative bacteria to increase the permeability of the membrane by promoting hydrophobic diffusion.
References:
[1]. Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. [2]. Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. [3]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.
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