Product Name :
RGD-4C
CAS NO. :
332179-76-7
Formula :
C69H103N19O23S3
Molecular Weight::
1662.86
Target:
Integrin
Serial Number:
Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly(Disulfide Bridge: Cys2-Cys10, Cys4-Cys8)
Short serial number :
ACCENLADTYRGPCF
Purity:
95%
Description :
RGD-4C binds preferentially to integrins αvβ3 and αvβ5. Both integrins are overexpressed in many cancers such as non-small cell lung cancer and melanoma and growing vessels.
References:
[1]. Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8. [2]. Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7. [3]. Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958.
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