Product Name :
Cilengitide
CAS NO. :
188968-51-6
Formula :
C27H40N8O7
Molecular Weight::
588.66
Target:
Integrin、Autophagy、Apoptosis、STAT、PD-1/PD-L1
Serial Number:
cyclo(Arg-Gly-Asp-DPhe-(NMe)Val)(main chain cyclo)
Short serial number :
cyclo(RG-{DPhe}-(NMe)V)(main chain cyclo)
Purity:
95%
Description :
The cyclic RGD peptide cilengitide is a potential cancer drug. Cilengitide is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.
References:
[1]. Kapp TG, et al. A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Sci Rep. 2017 Jan 11;7:39805. [2]. Hariharan S, et al. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrinreceptor antagonist, Cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol. 2007 Aug;18(8):1400-7. [3]. Pan X, et al. Cilengitide, an αvβ3-integrin inhibitor, enhances the efficacy of anti-programmed cell death-1 therapy in a murine melanoma model. Bioengineered. 2022 Feb;13(2):4557-4572.
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