Product Name: ONO-4059 hydrochloride
Chemical Name: (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride
SMILES Code: O=C(N1C[C@@H](CC1)N(C2=O)C3=NC=NC(N)=C3N2C4=CC=C(C=C4)OC5=CC=CC=C5)C#CC.[H]Cl
CAS NO: 140187-23-1 Product: ISRIB (trans-isomer)
Synonym: ONO4059 hydrochloride; ONO 4059 hydrochloride; GS4059 hydrochloride; GS 4059 hydrochloride; GS-4059 hydrochloride
Chemical Formula: C25H23ClN6O3
Appearance: Solid powderWeb Site：Medchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).NKCC inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: ONO-4059 (GS4059; ONO-WG-307; Tirabrutinib) is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18032922
