Product Name :
(D-Ala²)-Gastric Inhibitory Polypeptide (human)
CAS NO. :
444073-04-5
Formula :
C226H338N60O66S1
Molecular Weight::
4983.53
Target:
Insulin Receptor
Serial Number:
Tyr-DAla-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
Short serial number :
YaEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Purity:
95%
Description :
A highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD.
References:
[1]. Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. [2]. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. [3]. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease.
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