Product Name :
Thrombin Receptor Agonist
CAS NO. :
137339-65-2
Formula :
C81H118N20O23
Molecular Weight::
1739.92
Target:
Serial Number:
Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe
Short serial number :
SFLLRNPNDKYEPF
Purity:
95%
Description :
Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.
References:
[1]. Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action. [2].Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. [3]. Initiation of aspirin therapy modulates angiogenic protein levels in women with breast cancer receiving tamoxifen therapy. [4]. Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients.
Related websites: https://www.medchemexpress.com/antibodies.html
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