Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide | DNA

Product Name :
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide

CAS NO. :
207678-81-7

Formula :
C71H94N20O17S2

Molecular Weight::
1563.76

Target:
Melanocortin Receptor

Serial Number:
Ac-Cys-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2(Disulfide bridge:Cys1-Cys8)

Short serial number :
Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)

Purity:
≥95%

Description :
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide modulates the behavioral effects of morphine in mice. Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide increases food intake in free-feeding rats.

References:
[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: DNA_ Alkylatingdna

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