Product Name :
Big Gastrin – 1, human
CAS NO. :
60675-77-6
Formula :
C176H251N43O53S
Molecular Weight::
3849.3
Target:
Serial Number:
Pyr-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Short serial number :
Purity:
≥95%
Description :
Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin – Cat# AS-20750). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.
References:
Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980) Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x. O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848 Dockray, G. et.al. Pflügers Archiv 449,344 (2005) Bundgaard, JR. et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700 Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334
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