Product Name :
Caspase 1 Inhibitor VIII
CAS NO. :
189275-71-6
Formula :
C28H33O9N7
Molecular Weight::
611.60
Target:
Caspase
Serial Number:
Ac-Trp-Glu-His-Asp-CHO
Short serial number :
Ac-WEHD-CHO
Purity:
95%
Description :
Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
References:
[1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. [2]. Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55.
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