Product Name :
Caspase 1 (ICE) Inhibitor I
CAS NO. :
143313-51-3
Formula :
C23H32O8N4
Molecular Weight::
492.52
Target:
Interleukin Related，Apoptosis，Caspase
Serial Number:
Ac-Tyr-Val-Ala-Asp-CHO
Short serial number :
Ac-YVAD-CHO
Purity:
95%
Description :
Ac-YVAD-CHO is a potent, specific, reversible inhibitor of caspase-1 (ICE). It displayed a Ki of 0.2 ± 0.1 nM for recombinant human caspase-1.
References:
[1]. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248. [2]. Cao Y, et al. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin. 2005 Feb;26(2):150-4. [3]. Zhou X, et al. Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism. J Immunol. 2000 Aug 1;165(3):1252-8.
Related websites: https://www.medchemexpress.com/antibodies.html
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