Product Name :
ATI-2341 acetate
CAS NO. :
1337878-62-2
Formula :
C104H178O25N26S2
Molecular Weight::
2256.82
Target:
CXCR
Serial Number:
Palmiticacid-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu
Short serial number :
Palmiticacid-MGYQKKLRSMTDKYRL
Purity:
95%
Description :
ATI-2341 acetate is a potent and functionally selective CXCR4 allosteric agonist that activates Gα1 rather than Gα13. ATI-2341 acetate activates the inhibitory heterotrimer G protein (GI) to promote the inhibition of cAMP production and induce calcium mobilization.
References:
[1]. Quoyer J, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97. [2]. Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.
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