Product Name :
Cdc25A (80-93) (human)
CAS NO. :
851538-67-5
Formula :
C60H90N14O24S1
Molecular Weight::
1423.50
Target:
Biochemical Assay Reagents
Serial Number:
Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp
Short serial number :
TDSGFCLDSPGPLD
Purity:
95%
Description :
The abundance of Cdc25A fluctuates periodically during the cell division cycle, which is primarily modulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, Anaphase Promoting Complex/Cyclosome and Skp1/Cul1/F-box protein. Ubiquitylation and degradation occurs at mitotic exit and in G1 due to the presence of a destruction motif (KEN-box) in Cdc25A, while phosphorylation events regulate Cdc25A protein stability in S phase both in unperturbed cells and in cells exposed to DNA damaging agents or DNA replication inhibitors.
References:
[1]. Covell DG. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PLoS One. 2021 Apr 28;16(4):e0243336.
Related websites: https://www.medchemexpress.com/antibodies.html
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