Product Name :
Caspase 8 Inhibitor 1
CAS NO. :
191338-86-0
Formula :
C21H34O10N4
Molecular Weight::
502.52
Target:
Apoptosis
Serial Number:
Ac-Ile-Glu-Thr-Asp-CHO
Short serial number :
Ac-IETD-CHO
Purity:
95%
Description :
The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor.
References:
[1].A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. [2]. Inhibition of human caspases by peptide-based and macromolecular inhibitors. [3]. Sensitive and reliable JC-1 and TOTO-3 double staining to assess mitochondrial transmembrane potential and plasma membrane integrity: interest for cell death investigations.
Related websites: https://www.medchemexpress.com/antibodies.html
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