C124 ANPEP UBC CAPNS1 SPTBN1 ACTN1 RPLRPLP0 NUDTCSNK2A1 PSMG1 ANP32C KIF11 XPOT RIC8A TWFKRT8 GZMAMUTYHPOLBMYHTXNRDGZMK APEX1 interactor (not recognized) associated to RNA processing APEX1 interactor (not known) connected to transcription APEX1 interactor (recognized) APEX1 interactor (not known) related to DNA repair APEX1 interactor (not recognized) connected to other pathwaysEnzyme Ligand dependent nuclear receptor Phosphatase Translation regulator Other RelationshipKinase Peptidase Transcription regulator Transporter Function Relationshipb0 Repair of DNA n=(30) Excision repair n=(14) Double-stranded DNA break repair n=(15) Expression of RNA n=(47) Transcription n=(45) Metabolism of DNA n=(19) DNA harm n=(15) Damage of chromosomes n=(10) Transcription of RNA n=(40) Binding of DNA n=(20) Transcription of DNA n=(36) Transactivation of RNA n=(16) Splicing of RNA n=(10) Cell death n=(73) Apoptosis n=(65) Proliferation of cells n=(65) G2 phase n=(20) Interphase n=(28) Cell cycle progression N=(32) Cell proliferation of tumor cell lines n=(40) G2/M phase n=(14)DNA and RNA metabolismScore ( og p-value) 10 15Fig. 7 APE1 rotein interactome network. a Protein network generated by Ingenuity Pathway Analysis. Beginning in the gene list from the APE1-interacting protein partners, an interaction network was generated applying the “connect tool” in an effort to differentiate amongst identified or novel partners, also taking advantage with the Ingenuity Expertise base. By using the “annotation tool”, we selected and connected in the network the best four functional themes that were in a position to annotate the majority of the genes (63 ). Within the legend, we show the which means from the shape representation and the molecular relationships inside the IPA network. b Bar chart displaying the enrichment of distinct functions obtained working with IPA for the APE1-binding protein partners. Bars length represent the log P-value) in the enrichmentCell cycle and deathNATURE COMMUNICATIONS | eight:| DOI: 10.1038/s41467-017-00842-8 | nature.com/naturecommunicationsNATURE COMMUNICATIONS | DOI: 10.1038/s41467-017-00842-ARTICLEDNA recombination (four)Processing of RNA (three) ADAT1 (3) AHNAK (3) APP (1,two,three,5) ATXN3 (1,two,three) BUD13 (3,5) CDK11A (three,five) CDK13 (three,5) CLK3 (three) CPSF3L (1,three) CPSF6 (three,five) CTDP1 (3,5) DDX23 (three) DDX5 (1,3,5) DHX16 (3) DKC1 (two,3) GCFC2 (1,3,5) HNRNPA1 (1,three,five) HNRNPC (1,three,4,5) HNRNPL (three,5) IMP4 (three) KIAA0907 (three,5) NOL3 (three) NSRP1 (three,5) PABPC1 (three,four,5) PAPOLA (three,5) PLCB1 (1,three,five) QKI (three,five) RBM3 (three) RBPMS (3) RNPS1 (1,3,5) SAFB (1,three,5) SART3 (3,five) SRRM1 (3) SRSF5 (3,5) SRSF9 (3,five) SUPT5H (1,2,3,five) TARDBP (1,3) TRA2B (3,5) WBSCR22 (3)BANF1 (four) CHD4 (1,four) DNMT1 (1,four) FAAP24 (4) FBXO18 (four) HMGN1 (1,two,4) HNRNPC (1,three,four,five) KPNA1 (four) LIG4 (2,4) MLH1 (1,2,4) MSH5 (four) PABPC1 (3,4,5)POLB (2,four) REST (1,4) RFC2 (4) RPAIN (1,two,4) SPIDR (2,4) SUPT5H (1,3,four,5) TERT (1,2,4) TSN (4) UHRF1 (1,4) UNG (two,four) ZMYND8 (4)Repair of DNA (two) APP (1,two,3,five) APTX (two) ATF2 (1,2) ATXN3 (1,two,4) CDK2AP1 (2) CSNK1D (two) DEK (1,2) DKC1 (two,3) EIF4G1 (two) ENDOV (2) ERBB2 (1,two) EXD2 (two) FAN1I (two) FANCI (2) RIF1 (two) HMGN1 (1,2,four) RPAIN (1,two,4) INO80 (1,two) SMARCD3 LIG4 (two,four) (1,two) MDM2 (1,two) SMUG1 (two) MLH1 (1,2,four) SPIDR (two,four) MUTYH (two) TDG (1,two) NEIL1 (two) TERT (1,two,four) NFE2L1 (1,two) NR4A1 (1,2) TMEM161A (2) TP73 (1,two) POLB (2,4) UNG (two,four) POLD1 (2) UVRAG (two) POLI (two) POLK (2) RAD23B (two)Processing of mRNA (5) APP (1,2,three,five) BUD13 (three,5) CDK11A (three,5) CDK13 (3,five) CPSF6 (three,5) CTDP1 (3,5) DDX5 (1,three,five) GCFC2 (1,3,5) HNRNPA1 (1,3,5) HNRNPC (1,3,four,5) HNRNPL (three,5) KIAA0907 (three,5) N.VEGF-A Protein web VEGF-C Protein site PMID:28038441
