Product Name :
XMU-MP-1
Description:
XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively.
CAS:
2061980-01-4
Molecular Weight:
416.48
Formula:
C17H16N6O3S2
Chemical Name:
4-(2,9-dimethyl-8-oxo-6-thia-2,9,12,14-tetraazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-13-ylamino)benzene-1-sulfonamide
Smiles :
CN1C2=NC(NC3C=CC(=CC=3)S(N)(=O)=O)=NC=C2N(C)C(=O)C2SC=CC1=2
InChiKey:
YRDHKIFCGOZTGD-UHFFFAOYSA-N
InChi :
InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively.|Product information|CAS Number: 2061980-01-4|Molecular Weight: 416.48|Formula: C17H16N6O3S2|Chemical Name: 4-(2,9-dimethyl-8-oxo-6-thia-2,9,12,14-tetraazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-13-ylamino)benzene-1-sulfonamide|Smiles: CN1C2=NC(NC3C=CC(=CC=3)S(N)(=O)=O)=NC=C2N(C)C(=O)C2SC=CC1=2|InChiKey: YRDHKIFCGOZTGD-UHFFFAOYSA-N|InChi: InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 8 mg/mL (19.21 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Spironolactone Autophagy |Shelf Life: ≥12 months if stored properly.Oxalic acid Biochemical Assay Reagents |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33303624 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|At concentrations ranging from 0.1 to 10 μM, XMU-MP-1 reduces the phosphorylation of endogenous MOB1, LATS1/2, and YAP in HepG2 cells in a dose-dependent manner. XMU-MP-1 treatment inhibits hydrogen peroxide-stimulated MOB1 phosphorylation and MST1/2 autophosphorylation in a variety of cell lines, including mouse macrophage-like cells, human osteosarcoma, human colorectal adenocarcinoma cells. XMU-MP-1 blocks MST1/2 kinase activities, thereby activating the downstream effector Yes-associated protein and promoting cell growth. XMU-MP-1 can potently and reversibly suppress the activities of kinases MST1/2 and enhance their downstream YAP activation in cells.|In Vivo:|XMU-MP-1 displays excellent in in vivo pharmacokinetics and is able to augment mouse intestinal repair, as well as liver repair and regeneration, in both acute and chronic liver injury mouse models at a dose of 1 to 3 mg/kg via intraperitoneal injection. XMUMP-1 treatment exhibits substantially greater repopulation rate of human hepatocytes in the Fah-deficient mouse model than in the vehicle-treated control, indicating that XMU-MP-1 treatment might facilitate human liver regeneration.|Products are for research use only. Not for human use.|
