Product Name :
A-967079
Description:
A-967079 is a selective TRPA1 receptor antagonist with IC50s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS.
CAS:
1170613-55-4
Molecular Weight:
207.24
Formula:
C12H14FNO
Chemical Name:
(E)-N-[(1Z)-1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine
Smiles :
C/C(=C/C1C=CC(F)=CC=1)/C(/CC)=N/O
InChiKey:
HKROEBDHHKMNBZ-VMXLIBDNSA-N
InChi :
InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8-,14-12+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
A-967079 is a selective TRPA1 receptor antagonist with IC50s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS.|Product information|CAS Number: 1170613-55-4|Molecular Weight: 207.24|Formula: C12H14FNO|Chemical Name: (E)-N-[(1Z)-1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine|Smiles: C/C(=C/C1C=CC(F)=CC=1)/C(/CC)=N/O|InChiKey: HKROEBDHHKMNBZ-VMXLIBDNSA-N|InChi: InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8-,14-12+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (482.53 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.sn-Glycerol 3-phosphate References |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Systemic injection of A-967079 (30 μmol/kg, i.Rasburicase medchemexpress v.PMID:31986916 ) decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation of the ipsilateral hind paw in uninjured and CFA-inflamed rats. Similar to its actions in uninjured rats, administration of A-967079 (30 μmol/kg, i.v.) to complete Freund’s adjuvant (CFA)-inflamed rats significantly reduces WDR neuronal responses to noxious pinch stimulation compared to baseline firing (p=0.0013, repeated-measures ANOVA) and the vehicle group (p=0.0001, two-way ANOVA). The maximum observed effect (61.1±10.97% decrease from baseline levels) on pinch-evoked activity in inflamed rats occur 35 min after injection. In contrast to uninjured rats, injection of A-967079 to CFA-inflamed rats also significantly (p=0.0004, and p=0.0001 for the repeated-measures and two-way ANOVA’s, respectively) reduces responses of WDR neurons to 10-g von Frey hair stimulation. The maximal observed decrease in von Frey-evoked activity is 67.69±18.39% from baseline levels (35 min post-injection), and is thus comparable to the effects of A-967079 on pinch-evoked activity in inflamed rats.|Products are for research use only. Not for human use.|
