Product Name :
PF-06873600
Description:
PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity.
CAS:
2185857-97-8
Molecular Weight:
471.52
Formula:
C20H27F2N5O4S
Chemical Name:
6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methanesulfonylpiperidin-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one
Smiles :
C[C@@]1(O)CCC[C@H]1N1C2N=C(NC3CCN(CC3)S(C)(=O)=O)N=CC=2C=C(C(F)F)C1=O
InChiKey:
QIEKHLDZKRQLLN-FOIQADDNSA-N
InChi :
InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Dabigatran Cancer
Additional information:
PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.Indomethacin Anti-infection 09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.PMID:32897174 PF-06873600 has potential antineoplastic activity.|Product information|CAS Number: 2185857-97-8|Molecular Weight: 471.52|Formula: C20H27F2N5O4S|Chemical Name: 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methanesulfonylpiperidin-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one|Smiles: C[C@@]1(O)CCC[C@H]1N1C2N=C(NC3CCN(CC3)S(C)(=O)=O)N=CC=2C=C(C(F)F)C1=O|InChiKey: QIEKHLDZKRQLLN-FOIQADDNSA-N|InChi: InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (176.73 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-06873600 (Example 8) is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells.|Products are for research use only. Not for human use.|
