Product Name :
CCMI
Description:
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction.
CAS:
917837-54-8
Molecular Weight:
388.25
Formula:
C19H15Cl2N3O2
Chemical Name:
(2E)-N-(4-chlorophenyl)-3-[(4-chlorophenyl)amino]-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide
Smiles :
CC1C=C(ON=1)/C(=C\NC1C=CC(Cl)=CC=1)/C(=O)NC1C=CC(Cl)=CC=1
InChiKey:
VMAKIACTLSBBIY-GZTJUZNOSA-N
InChi :
InChI=1S/C19H15Cl2N3O2/c1-12-10-18(26-24-12)17(11-22-15-6-2-13(20)3-7-15)19(25)23-16-8-4-14(21)5-9-16/h2-11,22H,1H3,(H,23,25)/b17-11+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Tetraconazole MedChemExpress
Additional information:
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction.|Product information|CAS Number: 917837-54-8|Molecular Weight: 388.25|Formula: C19H15Cl2N3O2|Chemical Name: (2E)-N-(4-chlorophenyl)-3-[(4-chlorophenyl)amino]-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide|Smiles: CC1C=C(ON=1)/C(=C\NC1C=CC(Cl)=CC=1)/C(=O)NC1C=CC(Cl)=CC=1|InChiKey: VMAKIACTLSBBIY-GZTJUZNOSA-N|InChi: InChI=1S/C19H15Cl2N3O2/c1-12-10-18(26-24-12)17(11-22-15-6-2-13(20)3-7-15)19(25)23-16-8-4-14(21)5-9-16/h2-11,22H,1H3,(H,23,25)/b17-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (257.Pirtobrutinib Protein Tyrosine Kinase/RTK 57 mM; Need ultrasonic).PMID:33352618 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs.|References:|Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.Products are for research use only. Not for human use.|
