Product Name :
DDR1-IN-1 dihydrochloride
Description:
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM).
CAS:
1780303-76-5
Molecular Weight:
625.51
Formula:
C30H33Cl2F3N4O3
Chemical Name:
4-[(4-ethylpiperazin-1-yl)methyl]-N-4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl-3-(trifluoromethyl)benzamide dihydrochloride
Smiles :
Cl.Cl.CC1C=CC(=CC=1OC1=CC2CC(=O)NC=2C=C1)NC(=O)C1C=C(C(CN2CCN(CC2)CC)=CC=1)C(F)(F)F
InChiKey:
PBUOJKYQZINPKD-UHFFFAOYSA-N
InChi :
InChI=1S/C30H31F3N4O3.2ClH/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26;;/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Withaferin A custom synthesis
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM).Gap 26 Inhibitor |Product information|CAS Number: 1780303-76-5|Molecular Weight: 625.51|Formula: C30H33Cl2F3N4O3|Chemical Name: 4-[(4-ethylpiperazin-1-yl)methyl]-N-4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl-3-(trifluoromethyl)benzamide dihydrochloride|Smiles: Cl.PMID:31568220 Cl.CC1C=CC(=CC=1OC1=CC2CC(=O)NC=2C=C1)NC(=O)C1C=C(C(CN2CCN(CC2)CC)=CC=1)C(F)(F)F|InChiKey: PBUOJKYQZINPKD-UHFFFAOYSA-N|InChi: InChI=1S/C30H31F3N4O3.2ClH/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26;;/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 References:|Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.Products are for research use only. Not for human use.|
