Amyloid β- Protein (25-35)

Description :
The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.β-Amyloid is normally found in the brains of people with Alzheimer’s disease (AD) and is the main component of amyloid plaques in Alzheimer’s disease. The main forms of β-amyloid in the human brain are Aβ (1-40) and Aβ (1-42). However, studies have found that Aβ(25-35) fragments present in the brains of older adults are more toxic and are closely related to Alzheimer’s disease (AD) due to their unique aggregation.Aβ(25-35) is considered a functional domain of Aβ due to its neurotoxic effects, and it is the biologically active region of β-amyloid. Studies have shown that the injection of Aβ(25-35) fragments into the lateral ventricles of mice can cause amnesia, cause spatial learning and memory impairment in mice, and be accompanied by the decline of passive avoidance response.