Product Name :
(Nle³⁵)-Amyloid β-Protein (1-40)
CAS NO. :
1802086-31-2
Formula :
C195H297N53O58
Molecular Weight::
4311.76
Target:
Serial Number:
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val
Short serial number :
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL-Nle-VGGVV
Purity:
95%
Description :
The reactive thioether of Met³⁵ is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
References:
[1].Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity.
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