Product Name :
APL1β28
CAS NO. :
1233876-42-0
Formula :
C109H185N31O39S1
Molecular Weight::
2585.88
Target:
Serial Number:
Asp-Glu-Leu-Ala-Pro-Ala-Gly-Thr-Gly-Val-Ser-Arg-Glu-Ala-Val-Ser-Gly-Leu-Leu-Ile-Met-Gly-Ala-Gly-Gly-Gly-Ser-Leu
Short serial number :
DELAPAGTGVSREAVSGLLIMGAGGGSL
Purity:
95%
Description :
A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1. The peptide is generated by the same proteolytic mechanism as Aβ42. Non-amyloidogenic APL1β28 can be detected in the CSF and its levels correlate with Aβ42 production. Its ratio to total APL1β (APL1β25, APL1β27, and APL1β28) is significantly increased in familial and sporadic cases of AD.
References:
[1]. The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. [2]. Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.
Related websites: https://www.medchemexpress.com/antibodies.html
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