Product Name :
(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21)
CAS NO. :
2763585-09-5
Formula :
C33H43N5O8
Molecular Weight::
637.72
Target:
Serial Number:
Leu-Pro-Phe-Phe-Asp
Short serial number :
LPFFD
Purity:
95%
Description :
The pentapeptide LPFFD (iAβ5), a highly efficient β-sheet breaker, inhibited amyloid formation in vitro, prevented amyloid neurotoxicity in cell culture, reduced in vivo cerebral Aβ deposition and completely blocked amyloid fibril formation in rat brain.
References:
[1]. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits. [2]. Exploration of the mechanism for LPFFD inhibiting the formation of beta-sheet conformation of A beta(1-42) in water. [3]. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer’s therapy.
Related websites: https://www.medchemexpress.com/antibodies.html
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