Product Name :
Teplow’s Amyloid β-Protein (1-42) (scrambled II)
CAS NO. :
1987844-92-7
Formula :
C203H311N55O60S1
Molecular Weight::
4514.04
Target:
Amyloid-β
Serial Number:
Tyr-His-Ala-Gly-Val-Asp-Lys-Glu-Val-Val-Phe-Asp-Glu-Gly-Ala-Gly-Ala-Glu-His-Gly-Leu-Ala-Gln-Lys-Ile-Val-Arg-Gly-Phe-Gly-Val-Ser-Asp-Val-Ser-Met-Ile-His-Ile-Asn-Leu-Phe
Short serial number :
YHAGVDKEVVFDEGAGAEHGLAQKIVRGFGVSDVSMIHINLF
Purity:
95%
Description :
This peptide is a specifically designed negative control in studies with Abeta42. It is “scrambled”, which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow’s Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
References:
[1].Design, Characterization, and Use of a Novel Amyloid β-Protein Control for Assembly, Neurotoxicity, and Gene Expression Studies.
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