Product Name :
(Gln²²,Asn²³)-Amyloid β-Protein (1-40)
CAS NO. :
374796-75-5
Formula :
C194H297N55O56S1
Molecular Weight::
4327.83
Target:
Amyloid-β
Serial Number:
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asn-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
Short serial number :
DAEFRHDSGYEVHHQKLVFFAQNVGSNKGAIIGLMVGGVV
Purity:
95%
Description :
Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
References:
[1]. Inhibition of familial cerebral amyloid angiopathy mutant amyloid beta-protein fibril assembly by myelin basic protein. [2].Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. [3]. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Lokivetmab Cancer
Teplizumab medchemexpress
3-Nitrotyrosine Antibody: 3-Nitrotyrosine Antibody is an unconjugated, rabbit-derived, anti-3-Nitrotyrosine polyclonal antibody. 3-Nitrotyrosine Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, and predicted: mouse background without labeling.
