Product Name :
Thrombin Receptor Antagonist
CAS NO. :
207553-92-2
Formula :
C58H91N17O20S2
Molecular Weight::
1410.58
Target:
Serial Number:
Met-Ser-Arg-Pro-Ala-Cys-Pro-Asn-Asp-Lys-Tyr-Glu
Short serial number :
MSRPACPNDKYE
Purity:
95%
Description :
The peptide T1, MSRPACPNDKYE, is based on the sequence of the thrombin receptor domain that functions as a tethered ligand for the receptor itself. T1 has been selected from a phage peptide library as an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. MSRPACPNDKYE has served as model peptide in protein modification and MS studies.
References:
[1]. Identification of alternative products and optimization of 2-nitro-5-thiocyanatobenzoic acid cyanylation and cleavage at cysteine residues. [2]. Matrix-assisted laser desorption/ionization-MS-based relative quantification of peptides and proteins using iodoacetamide and N-methyliodoacetamide as labeling reagents [3].Isolation of a peptide antagonist to the thrombin receptor using phage display.
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