Product Name :
Calcitonin Gene Related Peptide (8-37), rat
CAS NO. :
129121-73-9
Formula :
C138H224N42O41
Molecular Weight::
3127.58
Target:
CGRP Receptor
Serial Number:
Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
Short serial number :
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂
Purity:
≥95%
Description :
Calcitonin Gene Related Peptide (8-37), rat, a competitive CGRP1 receptor antagonist, exhibited hypothermic and antinociceptive effects. CGRP-I (8-37) antagonized the effects of amylin and amylin (1-8) on osteoblasts but was substantially less potent in this regard than amylin (8-37). Furthermore, it inhibited the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.
References:
[1].Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney.P.J.Harris et al., Am. J. Physiol., 272, F13 (1997) [2].Dissociation of the effects of amylin on osteoblast proliferation and bone resorption.J.Cornish et al., Am. J. Physiol., 274, E827 (1998) [3].Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat.H.C.Champion et al., Am. J. Physiol., 272, R234 (1997) [4].Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.L.C.Yu et al., Regul. Pept., 83, 21 (1999) [5].The hypothermic and antinociceptive effects of intrathecal injection of CGRP (8-37) in mice.M.A.Saxen et al., Life Sci., 55, 1665 (1994) [6].Receptor subtypes mediating renal actions of calcitonin gene-related peptide.A.M.Elhawary et al., Eur. J. Pharmacol., 286, 255 (1995)
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