Product Name :
(Val²)-Amyloid β-Protein (1-42)
CAS NO. :
167114-91-2
Formula :
C205H315N55O60S1
Molecular Weight::
4542.09
Target:
Serial Number:
Asp-Val-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Short serial number :
DVEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Purity:
95%
Description :
A mutation very close to the β-secretase cleavage site of APP (A673V). Contrary to the protective Icelandic mutation A2T, the recessive A2V mutation may increase the risk of Alzheimer’s disease. Cantu et al. observed that APP A673V is associated with the early onset of AD-type dementia in homozygous individuals, whereas it has a protective effect in the heterozygous state.
References:
[1].Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. [2].High-yield cell-free synthesis of human EGFR by IRES-mediated protein translation in a continuous exchange cell-free reaction format. [3].A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition. [4]. Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction.
Related websites: https://www.medchemexpress.com/antibodies.html
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