Product Name :
(Thr²)-Amyloid β-Protein (1-42)
CAS NO. :
Formula :
C204H313N55O61S1
Molecular Weight::
4544.06
Target:
Serial Number:
Asp-Thr-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Short serial number :
DTEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Purity:
95%
Description :
A mutation very close to the β-secretase cleavage site of APP. The Icelandic mutation A2T of Aβ42 turned out to be less pathogenic than the native sequence. The precursor APP A673T was the first APP variant discovered in humans reducing the risk of Alzheimer’s disease. A2T as well affects γ-secretase cleavage, the mutant was an inefficient substrate in a cell-based assay of the enzyme.
References:
[1]. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells. [2]. A2T and A2V Aβ peptides exhibit different aggregation kinetics, primary nucleation, morphology, structure, and LTP inhibition. [3]. Alzheimer’s Protective Cross-Interaction between Wild-Type and A2T Variants Alters Aβ 42 Dimer Structure. [4].Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction.
Related websites: https://www.medchemexpress.com/antibodies.html
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