Product Name :
(Cys⁴⁷)-HIV-1 tat Protein (47-57)
CAS NO. :
627079-23-6
Formula :
C58H114N32O13S1
Molecular Weight::
1499.80
Target:
HIV
Serial Number:
Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH
Short serial number :
CGRKKRRQRRR
Purity:
95%
Description :
(Cys47)-HIV-1 tat Protein (47-57) has membrane translocation function and can be used to derivatize the surface of magnetic pharmaceuticals and substantially facilitated their uptake into target cells.It is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. The peptide contains a protein transduction domain (PTD) that inhibits HSV-1 entry into the HIV Tat protein. The addition of cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellular and immediately blocks the entry of adsorptive virus without eluting virions.
References:
[1]. Chumki Dalal, et al. Multivalency Effect of TAT-Peptide-Functionalized Nanoparticle in Cellular Endocytosis and Subcellular Trafficking. J Phys Chem B. 2017 Apr 13;121(14):2942-2951. [2]. Ming Zhao, et al. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. Jul-Aug 2002;13(4):840-4.
Related websites: https://www.medchemexpress.com/antibodies.html
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