α-Conotoxin SIA | DNA_ Alkylatingdna-alkylating.com

Product Name :
α-Conotoxin SIA

CAS NO. :
135190-31-7

Formula :
C60H82N18O17S4

Molecular Weight::
1455.7

Target:
nAChR

Serial Number:
Tyr-Cys-Cys-His-Pro-Ala-Cys-Gly-Lys-Asn-Phe-Asp-Cys-NH2 (Disulfide bridge: Cys2 -Cys7,Cys3 – Cys13)

Short serial number :
YCCHPACGKNFDC-NH2 (Disulfide bridge:Cys2-Cys7;Cys3-Cys13)

Purity:
≥95%

Description :
α-Conotoxin SIA is a selective nicotinic acetylcholine receptor (nAChR) antagonist with high affinity for the muscle nAChR. α-Conotoxin SIA preferentially targets the α/δ interface of the muscle nAChR in mouse muscle. In contrast, for Torpedo nAChR, α-Conotoxin SIA has a much higher affinity for the α/γ than for the α/δ interface.

References:
[1]. Layla Azam, et al. Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors. Acta Pharmacol Sin. 2009 Jun;30(6):771-83.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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