Product Name :
醋酸戈舍瑞林
CAS NO. :
145781-92-6
Formula :
C61H88N18O16
Molecular Weight::
1329.46
Target:
Serial Number:
H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2.CH3CO
Short serial number :
XHWSYXLRP
Purity:
≥98%
Description :
醋酸戈舍瑞林(ICI-118630 acetate)是促性腺激素释放激素(GnRH) /LHRH的十肽类似物，具有GnRH激动剂作用。醋酸戈舍雷林可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。醋酸戈舍瑞林是合成的黄体生成素释放激素(LHRH)十肽类似物的乙酸盐。男性持续、长期服用戈舍林可抑制垂体促性腺激素分泌，导致睾酮分泌显著下降;在女性中，长期服用会导致雌二醇分泌减少。(NCI04)
References:
[1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042. [Content Brief] [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.
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