Product Name :
Cholecystokinin Precursor (24-32) (rat)
CAS NO. :
99291-20-0
Formula :
C42H69N9O14S
Molecular Weight::
956.13
Target:
GCGR
Serial Number:
Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met
Short serial number :
VPVEAVDPM
Purity:
≥95%
Description :
Its mechanism of action is to act on pancreatic β cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of pancreatic islet β cells, inhibit the apoptosis of pancreatic islet β cells, increase the number of pancreatic islet β cells, and have the effect of protecting the function of pancreatic islets. It can also act on pancreatic islet α cells, inhibit the release of glutina Chemicalbook, and reduce the release of liver glucose. It acts on pancreatic islet δ cells, promotes the secretion of somatostatin, and participates in the inhibition of glucagon secretion. Enhance insulin sensitivity, slow down gastric emptying, act on the hypothalamus to suppress appetite, reduce body weight, and achieve the effect of lowering blood sugar through these effects.
References:
[1]. Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844. [2]. Zhang L, et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson’s disease mouse model. Neuropeptides. 2018 Oct;71:70-80. [3]. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284.
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