Product Name :
Cholecystokinin Octapeptide (2-8) (desulfated)
CAS NO. :
47910-79-2
Formula :
C45H57N9O10S2
Molecular Weight::
948.14
Target:
others
Serial Number:
Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2
Short serial number :
YMGWMDF-NH2
Purity:
≥95%
Description :
Cholecystokinin Octapeptide (2-8) (desulfated) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated Cholecystokinin Octapeptide (2-8) (desulfated) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 uMol/kg.
References:
[1]. Raybould, H.E., and Lloyd, K.C. Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways Ann. N.Y. Acad. Sci. 713(1), 143-156 (1994). [2]. Ondetti, M.A., Plu??ec, J., Sabo, E.F., et al. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide J. Am. Chem. Soc. 92(1), 195-199 (1970). [3]. Schiller, P.W., Lipton, A., Horrobin, D.F., et al. Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptor Biochem. Biophys. Res. Commun. 85(4), 1332-1338 (1978). [4]. Crawley, J.N., St-Pierre, S., and Gaudreau, P. Analysis of the behavioral activity of C- and N-terminal fragments of cholecystokinin octapeptide J. Pharmacol. Exp. Ther. 230(2), 438-444 (1984).
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
EIF2A Rabbit mAb custom synthesis
Olaratumab manufacturer
GRB2 Antibody (YA748): GRB2 Antibody (YA748) is a non-conjugated and Mouse origined monoclonal antibody about 25 kDa, targeting to GRB2 (5G3). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.
