Product Name :
十肽-12
CAS NO. :
137665-91-9
Formula :
C65H90N18O17
Molecular Weight::
1395.55
Target:
Tyrosinase; Sirtuin
Serial Number:
Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr
Short serial number :
YRSRKYSSWY
Purity:
95%
Description :
十肽12 (Decapeptide-12)是一种小分子的酪氨酸酶抑制剂，与酪氨酸酶c端残基(Kd: 61.1 μM)相互作用。十肽-12是蘑菇酪氨酸酶的竞争性抑制剂(IC50: 40µM)。也增加SIRT的转录，减少黑色素细胞中的黑色素含量。用于研究黑色素生成、衰老、炎症。
References:
[1]. Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. [2]. Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. [3]. Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.
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