Product Name :
WFY-pSer-PR-pNA
CAS NO. :
202739-41-1
Formula :
C49H59N12O13P1
Molecular Weight::
1055.04
Target:
Fluorescent Dye
Serial Number:
Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA
Short serial number :
WFY-pSer-PR-pNA
Purity:
95%
Description :
WFYpSPR-pNA, chromogenic substrate for Pin1, an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase), that specifically recognizes the phosphoserine-proline bonds present in mitotic phosphoproteins (kcat/Km = 20160 mM⁻¹s⁻¹).
References:
[1]. M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60. [2]. Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65.
Related websites: https://www.medchemexpress.com/antibodies.html
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