Product Name :
Z-AAN-AMC
CAS NO. :
149697-16-5
Formula :
C28H31O8N5
Molecular Weight::
565.57
Target:
others
Serial Number:
Cbz-Ala-Ala-Asn-AMC
Short serial number :
Z-AAN-AMC
Purity:
95%
Description :
Z-AAN-AMC, standard substrate for legumain (EC 3.4.22.34), was originally used for the plant enzyme and later to discover the mammalian form of the enzyme. Legumain may be a physiologic local regulator of human osteoclast (OCL) activity that can negatively modulate OCL.
References:
[1]. Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. [2]. James C. Powers, et al. Propenoyl hydrazides. US7482379B2. [3]. Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035.
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